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【Portfolio】VIVA朋友圈丨启愈生物将于2022年ASCO年会上公布其Q-1802的最新临床数据

May 31, 2022 | Source: Viva Biotech 维亚生物 

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中国,上海——日前,由维亚生物参与投资孵化的启愈生物宣布Q-1802项目的一期临床数据将于2022年美国临床肿瘤学会(ASCO)年会上公布。该研究结果摘要将于ASCO网站上发布>>https://meetings.asco.org/abstracts-presentations/210075

 

Q-1802 I期临床试验为首次在人体中进行的多中心、开放、单臂、剂量爬坡及剂量拓展研究。用于治疗标准治疗失败的耐药/难治性晚期或转移性实体瘤患者。该研究计划纳入20-30 名受试者并由北京大学肿瘤医院沈琳教授作为主要研究者主持进行。目前的阶段性研究数据表明,在10 mg/kg 的剂量下,Q-1802 表现出出色的初步安全性、耐受性和初步抗肿瘤活性。剂量爬坡及剂量扩展研究仍在继续。

 

该研究结果摘要刊登于ASCO年会摘要汇集(#2568)。北京大学肿瘤医院消化肿瘤科龚继芳博士将于6月5日报告相关结果。

关于Q-1802

 

Q-1802是由启愈生物自主开发的可以同时靶向CLDN18.2及PD-L1人源化双特异性抗体。Q-1802为FDA首个批准的并最先进入临床的CLDN18.2/PD-L1双抗。在机制上,Q-1802采用多种免疫机制来杀伤肿瘤细胞,为治疗CLDN18.2高表达晚期实体瘤的提供了全新治疗策略。Q-1802展示了优秀的临床前抗肿瘤及安全性数据,拥有良好的理化性质及可生产性(表达量达到4 g/L以上)。

 

关于启愈生物

 

启愈生物是一家专注于创新大分子生物药研发的国际化公司,致力于解决难治性癌症、自身免疫等临床亟需及未满足需求。公司由相关领域的资深科学家创立,目前已打造生物大分子开发的专有技术,包括双抗及三抗的创新平台。

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